Physical and chemical properties: appearance: white crystal melting point: 94-98 ℃
2,2-Dimethyl-1,3-dioxane-4,6-dione Usage And S： Crystals, white to beige
Uses Meldrum`s acid is an intermediate for different organic syntheses. For typical reactions please consult the Meldrum`s acid brochure, which you can order. Contact us. Product Data Sheet
Uses An antimicrobial agent
Uses In organic synthesis as a substitute for acyclic malonic esters and generally as a C3O2 synthon.
Synonyms:MELDRUMS ACID;'MELDRUM'S ACID';MELDRUM'S ACID;MALONIC ACID CYCLIC ISOPROPYLIDENE ESTER;LABOTEST-BB LT00233174;Isopropyl Malonate;Meldrum’s acid, Malonic acid cyclic isopropylidene ester;2,2-DiMethyl-1,3-dioxane-4,6-dione, 98% 25GR
CAS:2033-24-1
MF:C6H8O4
MW:144.13
EINECS:217-992-8
Product Categories:Drug Discovery;Dioxanes;Dioxanes & Dioxolanes;pharmaceutical intermediates;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
2,2-Dimethyl-1,3-dioxane-4,6-dione Chemical Properties
Melting point 92-96 °C(lit.)
Boiling point 182.71°C (rough estimate)
density 1.1311 (rough estimate)
refractive index 1.4434 (estimate)
storage temp. 0-6°C
solubility dioxane: soluble5%, clear to very slightly hazy, colorless to faintly yellow
pka5.1(at 25℃)
form Crystals or Powder
color Brownish-white to beige-brown
Water Solubility 2.5 g/100 mL (20 oC)
Merck 14,5817
BRN 117310
InChIKeyGXHFUVWIGNLZSC-UHFFFAOYSA-N
CAS DataBase Reference2033-24-1(CAS DataBase Reference)
NIST Chemistry Reference1,3-Dioxane-4,6-dione, 2,2-dimethyl-(2033-24-1)
EPA Substance Registry System1,3-Dioxane-4,6-dione, 2,2-dimethyl- (2033-24-1)
Safety Information
Hazard Codes Xi,T
Risk Statements 36/37/38-45
Safety Statements 37/39-24/25-53-45-36-26
WGK Germany 3
RTECS JH0800000
F 10-21
TSCA Yes
HazardClass IRRITANT
HS Code 29322090
2,2-Dimethyl-1,3-dioxane-4,6-dione Usage And Synthesis
Chemical PropertiesCrystals, white to beige
UsesMeldrum`s acid is an intermediate for different organic syntheses. For typical reactions please consult the Meldrum`s acid brochure, which you can order. Contact us. Product Data Sheet
UsesAn antimicrobial agent
UsesIn organic synthesis as a substitute for acyclic malonic esters and generally as a C3O2 synthon.
Synthesis Reference(s)Journal of the American Chemical Society, 70, p. 3426, 1948 DOI: 10.1021/ja01190a060
Purification MethodsCrystallise the dione from Me2CO/H2O. It is a synthon for the C3 malonic acid moiety. [Arnette et al. J Am Chem Soc 106 6759 1984, Bihlmayer et al. Monatsh Chem 98 564 1967, Review: McNab Chem Soc, Rev 7 345 1978, Chan & Huang Synthesis 452 1982, Beilstein 19/5 V 8.]
